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Preserve biological complexity. Achieve molecular resolution.

Developing and applying an integrated toolkit across molecular scales.

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Single Molecule Imaging

Measure stoichiometry, dynamics, and molecular heterogeneity

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Native Nanodisc Technology

Isolate nanoscale membrane patches while preserving native context

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Cryo-EM  &
Structural Biology

Reveal structures and conformational states that underlie signaling

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Native MS, Proteomics, 
& Lipidomics

Identify protein assemblies and lipid environments linked to function

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Biochemistry & Electrophysiology

Connect molecular mechanisms to signaling and cellular function

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Computational & Integrative Modeling

Integrate data across scales to generate and test mechanistic models

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