
Overview
The Bhattacharyya Lab employs an integrative approach to understand the molecular mechanism for the regulation and activation of kinase signalling pathways in the context of learning and memory, and cognitive impairments in Down Syndrome.
Overview
The Bhattacharyya Lab employs an integrative approach to understand the molecular mechanism for the regulation and activation of kinase signalling pathways in the context of learning and memory, and cognitive impairments in Down Syndrome.
Overview
The Bhattacharyya Lab employs an integrative approach to understand the molecular mechanism for the regulation and activation of kinase signalling pathways in the context of learning and memory, and cognitive impairments in Down Syndrome.
The hattacharyya Lab

Selected Publications
Research articles
Caroline Brown, Snehasish Ghosh, Rachel McAllister, Mukesh Kumar, Gerard Walker, Eric Sun, Talat Aman, Aniruddha Panda, Shailesh Kumar, Wenxue Li, Jeff Coleman, Yansheng Liu, James E Rothman, Moitrayee Bhattacharyya, Kallol Gupta. A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs. Nat Methods. 2025 Feb;22(2):412-421. doi: 10.1038/s41592-024-02517-x. Epub 2024 Nov 28. PubMed PMID: 39609567; PubMed Central PMCID: PMC11810782.
James R Occean, Na Yang, Yan Sun, Marshall S Dawkins, Rachel Munk, Cedric Belair, Showkat Dar, Carlos Anerillas, Lin Wang, Changyou Shi, Christopher Dunn, Michel Bernier, Nathan L Price, Julie S Kim, Chang-Yi Cui, Jinshui Fan, Moitrayee Bhattacharyya, Supriyo De, Manolis Maragkakis, Rafael de Cabo, Simone Sidoli, Payel Sen. Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging. Nat Commun. 2024 Jul 28;15(1):6357. doi: 10.1038/s41467-024-50725-y. PubMed PMID: 39069555; PubMed Central PMCID: PMC11284234.
Gerard Walker, Caroline Brown, Xiangyu Ge, Shailesh Kumar, Mandar D Muzumdar, Kallol Gupta, Moitrayee Bhattacharyya. Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution. Nat Nanotechnol. 2024 Jan;19(1):85-94. doi: 10.1038/s41565-023-01547-4. Epub 2023 Nov 27. PubMed PMID: 38012273; PubMed Central PMCID: PMC10981947
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Cover Article, January Issue, 2024.
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Highlighted in News &Views in Nature Nanotechnology: Mitra K, Krishnan Y. Lightly counting membrane proteins in native nanodiscs. Nature Nanotechnology, 19, 5–6 (2024), DOI: 10.1038/s41565-023-01538-5, PMID: 38012272
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Highlighted in Yale News: https://news.yale.edu/2023/12/20/using-molecular-cookie-cutters-view-membrane- protein-organization
Fabian Giska, Malaiyalam Mariappan, Moitrayee Bhattacharyya, Kallol Gupta. Deciphering the molecular organization of GET pathway chaperones through native mass spectrometry. Biophys J. 2022 Apr 5;121(7):1289-1298. doi: 10.1016/j.bpj.2022.02.026. Epub 2022 Feb 19. PubMed PMID: 35189106; PubMed Central PMCID: PMC9034188.
Before Yale:
Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioglu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T. Groves, John Kuriyan, Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation. eLife, 9, e53670 (2020). PMCID: PMC7141811
Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia, Young Kwang Lee, Serena Muratcioglu, Darren McAffee, Ethan McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams, John Kuriyan, 2020. Breakage of the oligomeric camkii hub by the regulatory segment of the kinase. eLife 2020;9:e57784 DOI: 10.7554/eLife.57784 (2020). PMCID: PMC7538161.
Moitrayee Bhattacharyya, Margaret M. Stratton, Catherine C. Going, Ethan McSpadden, Yongjian Huang, Anna C. Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine Gee, Tiago Barros, Howard Schulman, Evan R. Williams, John Kuriyan, Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II, eLife, 5, e13405 (2016).PMCID: PMCID4859805
Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves, John Kuriyan, Activation-triggered subunit exchange between CamKII holoenzyme facilitates the spread of kinase activity, eLife, 3, e01610 (2014). PMCID: PMCID3920281
Moitrayee Bhattacharyya, Kallol Gupta, Konkallu Hanumae Gowd, and Padmanabhan Balaram, Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins, Mol BioSystems, 9, 1340 (2013). doi: 10.1039/C3MB25534D.PMID: 23467691
Moitrayee Bhattacharyya, Chanda R Bhat, and Saraswathi Vishveshwara, An automated approach to network features of protein structure ensembles, Protein Science, 22, 1399 (2013). PMCID: PMC3795498
Moitrayee Bhattacharyya and Saraswathi Vishveshwara, Probing the allosteric mechanism in pyrrolysyl-tRNA synthetase using energy-weighted network formalism, Biochemistry, 50, 6225 (2011). doi: 10.1021/bi200306u. PMID: 21650159
Underlined = equal contributions
Bold = lab members
Reviews
Moitrayee Bhattacharyya, Deepti Karandur, John Kuriyan. Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII). Cold Spring Harb Perspect Biol., 2019, doi: 10.1101/cshperspect.a035147. PMCID: PMC7263085
Moitrayee Bhattacharyya, Soma Ghosh, and Saraswathi Vishveshwara, Protein Structure and Function: Looking through the Network of Side-Chain Interactions, Current Protein and Peptide Science, 17, 4 (2016). PMID: 26412788
Anushka Halder, Arinnia Anto, Varsha Subramanyan, Moitrayee Bhattacharyya, Smitha Vishveshwara and Saraswathi Vishveshwara (2020) Surveying the Side-Chain Network Approach to Protein Structure and Dynamics: The SARS-CoV-2 Spike Protein as an Illustrative Case. Front. Mol. Biosci. 7:596945. doi: 10.3389/fmolb.2020.596945 PMCID: PMC7775578